Juan C. Landoni, Ph.D.
Mitochondria | Metabolism | Ageing | Microscopy
Research Focus
Dissecting the dynamic orchestration between mitochondria and metabolism
underlying health, disease and ageing
using advanced imaging and integrative multi-omics
Key Publications
Pearling Drives Mitochondrial DNA Nucleoid Distribution
BioRxiv (2025)
doi
Overactive mitochondrial DNA replication disrupts perinatal cardiac maturation
Nature Communications (2024)
doi
Mitochondrial Structure, Dynamics, and Physiology: Light Microscopy to Disentangle the Network
Annual Review of Cell and Developmental Biology (2024)
doi
IMPDH2: A new gene associated with dominant juvenile-onset dystonia-tremor disorder
European Journal of Human Genetics (2021)
doi
Defects in mtDNA replication challenge nuclear genome stability
Nature Metabolism (2019)
doi
A complex genomic locus drives mtDNA replicase POLG expression to its disease‐related nervous system regions
EMBO Molecular Medicine (2017)
doi
Outreach & Public Engagement
Recent Updates
Stoked to share TWO preprints on mitochondrial pearling! 🎉 We uncover how spontaneous #mitochondria pearling drives #mtDNA nucleoid distribution (doi.org/10.1101/2024...), and @gavsturm.bsky.social et al. dissect the biophysics behind it (doi.org/10.1101/2024...). Details below! 🔬🧵🧪
In case you haven't heard, #Argentinian scientists are live-streaming their deep-sea mission with real-time interactive commentary. It's genius, mesmerising, and triggering huge public interest and support for #science funding 🐙🧪 And the memes are great! #CONICET #MarDelPlataCanyon
#StarterPack for the #Mitochondria research community! Very much a work in progress, comment below/reach out to be added! #Mito #Mitochondriac go.bsky.app/J6Bu5fL