Juan C. Landoni, Ph.D.

Mitochondria | Quantitative Imaging | Translational Metabolism | Ageing

Dissecting the dynamic orchestration between mitochondria and metabolism underlying health, disease and ageing using advanced imaging and integrative multi-omics

SCIENTIFIC RESEARCH FOCUS

Mitochondria | Quantitative Imaging | Translational Metabolism | Ageing

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Mitochondrial & mtDNA dynamics

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Spatiotemporal metabolic coordination

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Mitochondrial disease & aging

KEY PUBLICATIONS

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Landoni, J. C.^✉, Lycas, M., Macuada, J., Jaccard, R., Obara, C., … Manley, S.^✉ Landoni, J. C.^✉ et al. Pearling Drives Mitochondrial DNA Nucleoid Distribution. Science (2026) Winter, J.*, Landoni, J.C.*, Holt, K., Ben Nejma, S., ... Koslover, E.F., Manley, S.^✉ Winter, J.*, Landoni, J.C.* et al. Asymmetric mitochondrial trafficking maintains network morphology by balancing perinuclear biogenesis. BioRxiv (2025) Landoni, J. C.*, Kleele, T.*^✉, Winter, J., Stepp, W., & Manley, S.^✉ Landoni, J. C.*, Kleele, T.* et al. Mitochondrial Structure, Dynamics, and Physiology: Light Microscopy to Disentangle the Network. Annual Review of Cell and Developmental Biology (2024) Landoni, J. C.^✉, Erkul, S., Laalo, T., Goffart, S., Kivelä, R., ... Suomalainen, A.^✉ Landoni, J. C.^✉ et al. Overactive mitochondrial DNA replication disrupts perinatal cardiac maturation. Nature Communications (2024) Kuukasjärvi, A.*, Landoni, J. C.*, Kaukonen, J., Juhakoski, M., ... Suomalainen, A.^✉ Kuukasjärvi, A.*, Landoni, J. C.* et al. IMPDH2: A new gene associated with dominant juvenile-onset dystonia-tremor disorder. European Journal of Human Genetics (2021) Hämäläinen, R. H., Landoni, J. C.*, Ahlqvist, K. J.*, Goffart, S., ... Suomalainen, A.^✉ Hämäläinen, R. H., Landoni, J. C.* et al. MtDNA replication defects challenge nuclear genome stability and provide a unifying mechanism for mouse progerias. Nature Metabolism (2019)

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