Juan C. Landoni, Ph.D.

Mitochondria | Metabolism | Ageing | Microscopy

Research Focus

Dissecting the dynamic orchestration between mitochondria and metabolism
underlying health, disease and ageing
using advanced imaging and integrative multi-omics

Metabolism

Metabolic reprogramming in mitochondrial disease & ageing

Imaging of mitochondrial pearling dynamics

Mitochondrial Dynamics

Mitochondrial dynamics & mtDNA nucleoid homeostasis

C elegans gonad with labeled mitochondria

Metabolic Coordination

Tissue-specific spatiotemporal coordination of metabolism

Key Publications

† Corresponding authors, * equal contributions

Pearling Drives Mitochondrial DNA Nucleoid Distribution

Landoni, J. C.†, Lycas, M., Macuada, J., Jaccard, R., Obara, C., Moore, A., … Manley, S.†

BioRxiv (2025)

Overactive mitochondrial DNA replication disrupts perinatal cardiac maturation

Landoni, J. C.†, Erkul, S., Laalo, T., Goffart, S., Kivelä, R., Skube, K., ... Suomalainen, A.†

Nature Communications (2024)

Mitochondrial Structure, Dynamics, and Physiology: Light Microscopy to Disentangle the Network

Landoni, J. C.*, Kleele, T.*, Winter, J., Stepp, W., & Manley, S.

Annual Review of Cell and Developmental Biology (2024)

IMPDH2: A new gene associated with dominant juvenile-onset dystonia-tremor disorder

Kuukasjärvi, A.*, Landoni, J. C.*, Kaukonen, J., Juhakoski, M., Auranen, M., ... Suomalainen, A.

European Journal of Human Genetics (2021)

Defects in mtDNA replication challenge nuclear genome stability

Hämäläinen, R. H., Landoni, J. C.*, Ahlqvist, K. J.*, Goffart, S., Ryytty, S., ... Suomalainen, A.

Nature Metabolism (2019)

A complex genomic locus drives mtDNA replicase POLG expression to its disease‐related nervous system regions

Nikkanen, J.*, Landoni, J. C.*, Balboa, D., Haugas, M., Partanen, J., Paetau, A., ... Suomalainen, A.

EMBO Molecular Medicine (2017)

Outreach & Public Engagement

MBL Physiology Course

Swiss Biology Olympiad Selective

Ctrl + Z — Cellular Reprogramming

Yttrium 39 - Periodic Table

World Mitochondrial Disease Week

Mitochondrial Musical - GYSS

Dato Encerrado Podcast

Ctrl + F — Genome Editing

Science Basement Podcast

Outreach & Scicomm News

Contact

Google Scholar

ORCID

Bluesky

GitHub

Twitter

EPFL

Recent Updates

@jclandoni.bsky.social

Juan C. Landoni

@jclandoni.bsky.social

Stoked to share TWO preprints on mitochondrial pearling! 🎉 We uncover how spontaneous #mitochondria pearling drives #mtDNA nucleoid distribution (doi.org/10.1101/2024...), and @gavsturm.bsky.social et al. dissect the biophysics behind it (doi.org/10.1101/2024...). Details below! 🔬🧵🧪

August 10, 2025

Juan C. Landoni

@jclandoni.bsky.social

In case you haven't heard, #Argentinian scientists are live-streaming their deep-sea mission with real-time interactive commentary. It's genius, mesmerising, and triggering huge public interest and support for #science funding 🐙🧪 And the memes are great! #CONICET #MarDelPlataCanyon

Juan C. Landoni

@jclandoni.bsky.social

#StarterPack for the #Mitochondria research community! Very much a work in progress, comment below/reach out to be added! #Mito #Mitochondriac go.bsky.app/J6Bu5fL